L-Arginine reverses maternal and pre-pubertal codeine exposure-induced sexual dysfunction via upregulation of androgen receptor gene and NO/cGMP signaling.
Roland Eghoghosoa AkhigbeOladele A AfolabiAyodeji Folorunsho AjayiPublished in: PloS one (2022)
In conclusion, codeine programmed sexual dysfunction by suppressing the levels of dopamine and testosterone, as well as repressing the expression of androgen receptor mRNA. In addition, codeine-induced epigenetic reprogramming was expressed in the F2 offsprings as reduced litter size and weight, and survival rate. Notably, these observations were worsened by prepubertal codeine exposure, but dampened by prepubertal arginine treatment.
Keyphrases
- nitric oxide
- poor prognosis
- high glucose
- diabetic rats
- oxidative stress
- mental health
- gene expression
- drug induced
- binding protein
- physical activity
- cell proliferation
- signaling pathway
- replacement therapy
- genome wide
- endothelial cells
- metabolic syndrome
- amino acid
- pregnancy outcomes
- protein kinase
- growth hormone
- stress induced