The Hypercoagulable Profile of Patients with Bone Tumors: A Pilot Observational Study Using Rotational Thromboelastometry.

Andreas G TsantesIlectra LoukopoulouDimitrios V PapadopoulosIoannis G TrikoupisAnastasios G RoustemisStavros GoumenosRozeta SokouKonstantina A TsanteAnastasios G KriebardisPanagiotis KoulouvarisDimitra HouhoulaDaniele PiovaniPanayiotis J PapagelopoulosStefanos BonovasArgirios E Tsantes

Published in: Cancers (2022)

Our results support the advantageous use of a ROTEM in patients with bone tumors over conventional coagulation tests because the qualitative changes in the hemostatic profile of these patients that can be detected by a ROTEM analysis cannot be identified by conventional tests. The ROTEM results indicate that the hypercoagulable state in patients with bone tumors is caused by the malignancy-associated activation of the coagulation cascade, platelet activation, and hypofibrinolysis.

Keyphrases

bone mineral density
end stage renal disease
soft tissue
bone loss
ejection fraction
newly diagnosed
bone regeneration
peritoneal dialysis
systematic review
randomized controlled trial
clinical trial
patient reported outcomes
patient reported