Factors associated with phosphatidylethanol (PEth) sensitivity for detecting unhealthy alcohol use: An individual patient data meta-analysis.
Judith A HahnPamela M MurnaneEric VittinghoffWinnie R MuyindikeNneka I EmenyonuRobin FatchGabriel ChamieJessica E HabererJoel Msafiri FrancisSaidi KapigaKaren Rita JacobsonBronwyn MyersMarie-Claude CoutureRalph Joseph DiClementeJennifer L BrownKaku A So-ArmahMark S SulkowskiGregory M MarcusSarah E Woolf-KingRobert L CookVeronica L RichardsPatricia E MolinaTekeda F FergusonDavid A WelshMariann R PianoShane A PhillipsScott StewartMajid AfsharKimberly PageKathleen McGinnisDavid A FiellinAmy C JusticeKendall J BryantRichard SaitzPublished in: Alcoholism, clinical and experimental research (2021)
Among people reporting unhealthy alcohol use, several biological factors (hemoglobin, BMI, liver fibrosis, and HIV status) were associated with PEth sensitivity. Race/ethnicity was associated with PEth sensitivity in some models but age, sex, and method of blood collection were not. Clinicians should be aware of these factors, and researchers should consider adjusting analyses for these characteristics where possible.