HLA signatures as pathophysiological discriminants of microscopic colitis subtypes.
Tenghao ZhengGiulia RodaYamile ZabanaCelia Escudero-HernándezXingrong LiuYe ChenPaulo Caleb Júnior Lima SantosFerdinando BonfiglioMarie-Rose MellanderIzabella JanczewskaLina VigrenKlas SjöbergBodil OhlssonSven AlmerJonas HalfvarsonStephan MiehlkeAhmed MadischWolfgang LiebJuozas KupčinskasRinse K WeersmaLuis BujandaAntonio JuliàSara MarsalMaria EsteveDanila GuagnozziFernando Fernández-BañaresCarmen Ferrernull nullInga PeterJonas F LudvigssonDarrell S PardiBas VerhaeghDaisy JonkersMarieke J PierikAndreas MünchAndre FrankeFrancesca BressoHamed KhaliliJean Frederic ColombelMauro D'AmatoPublished in: Journal of Crohn's & colitis (2023)
Our results suggest CC and LC have distinct pathophysiological underpinnings, characterised by an HLA predisposing role only in CC. This challenges existing classifications, eventually calling for a re-evaluation of the utility of MC umbrella definitions.