A reference profile-free deconvolution method to infer cancer cell-intrinsic subtypes and tumor-type-specific stromal profiles.
Li WangRobert P SebraJohn P SfakianosKimaada AlletteWenhui WangSeungyeul YooNina BhardwajEric E SchadtXin YaoMatthew D GalskyJun ZhuPublished in: Genome medicine (2020)
DeClust is a useful tool for cancer cell-intrinsic molecular subtyping of solid tumors. DeClust subtypes, together with the tumor-type-specific stromal profiles generated by this pan-cancer study, may lead to mechanistic and clinical insights across multiple tumor types.