More severe parotid gland histopathology in paediatric-onset than in adult-onset Sjögren's disease.

Geertje Elizabeth Legger Uzma Nakshbandi Martha S van GinkelSilvia C LiefersLisette de WolffAlja J StelWineke ArmbrustFred K L SpijkervetArjan VissinkSuzanne ArendsHendrika BootsmaBert van der VegtGwenny M VerstappenFrans G M Kroese

Published in: RMD open (2024)

Patients with pedSjD exhibit more pronounced histopathological features compared with patients with adSjD at diagnosis. Notably, the histopathology of patients with pedSjD aligns more closely with that observed in an adSjD clinical trial cohort, with even stronger B lymphocyte involvement.

Keyphrases

clinical trial
intensive care unit
emergency department
early onset
phase ii
disease activity
peripheral blood
open label
study protocol
double blind
randomized controlled trial
rheumatoid arthritis
systemic lupus erythematosus
phase iii