Invigorating human MSCs for transplantation therapy via Nrf2/DKK1 co-stimulation in an acute-on-chronic liver failure mouse model.

Feng ChenZhaodi CheYingxia LiuPingping LuoLu XiaoYali SongCunchuan WangZhiyong DongMianhuan LiGeorge L TipoeMin YangYi LvHong ZhangFei WangJia Xiao

Published in: Gastroenterology report (2024)

Co-stimulation with Nrf2/DKK1 safely improved the efficacy of human MSC-based therapies in murine models of ACLF through CKAP4-dependent paracrine mechanisms.

Keyphrases

liver failure
endothelial cells
hepatitis b virus
mouse model
oxidative stress
induced pluripotent stem cells
pluripotent stem cells
mesenchymal stem cells
stem cells