Cross-sectional Associations of β-Amyloid, Tau, and Cerebrovascular Biomarkers With Neurodegeneration in Probable Dementia With Lewy Bodies.
Daniel FerreiraScott A PrzybelskiTimothy G LesnickChristopher G SchwarzPatricia Diaz-GalvanJonathan Graff-RadfordMatthew L SenjemJulie A FieldsDavid S KnopmanDavid T JonesRodolfo SavicaTanis J FermanNeill Graff-RadfordVal J LoweClifford R JackRonald C PetersenErik WestmanBradley F BoeveKejal KantarciPublished in: Neurology (2022)
Probable DLB patients have widespread cortical atrophy, most of which likely is influenced by alpha-synuclein-related pathology. Although cerebrovascular, β-amyloid, and tau pathologies often coexist in probable DLB, their contributions to neurodegeneration seem to be region-specific.