Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model.

Xueyan GouFenglin RanJinru YangYanrong MaXin-An Wu

Published in: Pharmaceutics (2022)

These results demonstrate that this rat model is a useful tool for investigating the functions of OAT1/OAT3 in metabolic diseases, drug metabolism and pharmacokinetics, and OATs-mediated drug interactions.

Keyphrases

crispr cas
genome editing
ionic liquid
water soluble
adverse drug
drug induced
wild type