Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis.
Ellis VoermanSusana SantosBernadeta Patro GolabPilar AmianoFerran BallesterHenrique BarrosAnna BergströmMarie Aline CharlesLeda ChatziCécile ChevrierGeorge P ChrousosEva CorpeleijnNathalie CostetSarah R CrozierGraham DevereuxMerete Åse EggesbøSandra EkströmMaria Pia FantiniSara FarchiFrancesco ForastiereVagelis GeorgiuKeith M GodfreyDavide GoriChristine PrellWojciech HankeIrva Hertz-PicciottoBarbara HeudeDaniel HryhorczukRae-Chi HuangHazel M InskipNina IszattAnne M KarvonenLouise C KennyBerthold V KoletzkoLeanne K KüpersHanna LagströmIrina LehmannPer MagnusRenata MajewskaJohanna MäkeläYannis ManiosFionnuala M McAuliffeSheila W McDonaldJohn MeheganMonique MommersCamilla S MorgenTrevor A MoriGeorge MoschonisDeirdre MurrayCarol Ní ChaoimhEllen Aagaard NohrAnne-Marie Nybo AndersenEmily OkenAdriëtte J J M OostvogelsAgnieszka PacEleni PapadopoulouJuha PekkanenCostanza PizziPolańska KingaDaniela PortaLorenzo RichiardiSheryl L Rifas-ShimanLuca RonfaniAna Cristina SantosMarie StandlCamilla StoltenbergElisabeth ThieringCarel ThijsMaties TorrentSuzanne C ToughTomas TrnovecStephen W TurnerLenie van RossemAndrea von BergMartine VrijheidTanja G M VrijkotteJane WestAlet WijgaJohn WrightOleksandr ZvinchukThorkild I A SørensenDeborah A LawlorRomy GaillardVincent W V JaddoePublished in: PLoS medicine (2019)
In this study, higher maternal pre-pregnancy BMI and gestational weight gain were associated with an increased risk of childhood overweight/obesity, with the strongest effects at later ages. The additional effect of gestational weight gain in women who are overweight or obese before pregnancy is small. Given the large population impact, future intervention trials aiming to reduce the prevalence of childhood overweight and obesity should focus on maternal weight status before pregnancy, in addition to weight gain during pregnancy.
Keyphrases
- weight gain
- birth weight
- pregnancy outcomes
- body mass index
- weight loss
- pregnant women
- systematic review
- preterm birth
- early life
- childhood cancer
- randomized controlled trial
- physical activity
- bariatric surgery
- type diabetes
- risk factors
- adipose tissue
- metabolic syndrome
- electronic health record
- young adults
- insulin resistance
- big data
- current status
- high fat diet induced