Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study.
Aria FallahEvan LewisGeorge M IbrahimOlivia KolaChi-Hong TsengWilliam B HarrisJia-Shu ChenKao-Min LinLi-Xin CaiQing-Zhu LiuJiu-Luan LinWen-Jing ZhouGary W MathernMatthew D SmythBrent R O'NeillRoy W R DudleyJohn RaghebSanjiv BhatiaDaniel DelevGeorgia RamantaniJosef ZentnerAnthony C WangChristian DorferMartha FeuchtThomas CzechRobert J BolloGalymzhan IssabekovHongwei ZhuMary ConnollyPaul SteinbokJian-Guo ZhangKai ZhangEveline Teresa HidalgoHoward L WeinerLily Wong-KisielSamuel Lapalme-RemisManjari TripathiPoodipedi Sarat ChandraWalter HaderFeng-Peng WangYi YaoPierre-Olivier ChampagneTristan Brunette-ClémentQiang GuoShao-Chun LiMarcelo BudkeMaria Angeles Pérez-JiménezChristian RaftopoulosPatrice FinetPauline MichelKarl SchallerMartin N StienenValentina BaroChristian Cantillano MaloneJuan PociechaNoelia ChamorroValeria L MuroMarec von LeheSilvia ViekerChima OluigboWilliam Davis GaillardMashael Al-KhateebFaisal Al OtaibiNiklaus KrayenbühlJeffrey BoltonPhillip L PearlAlexander G WeilPublished in: Epilepsia (2021)
This pilot study demonstrated more durable seizure freedom of the vertical technique compared to lateral hemispherotomy techniques. Further studies, such as prospective expertise-based observational studies or a randomized clinical trial, are required to determine whether a vertical approach to hemispheric surgery provides superior long-term seizure outcomes.