Sildenafil improves exercise capacity in patients with cystic fibrosis: a proof-of-concept clinical trial.

Paula Rodriguez-MiguelezHaruki IshiiNichole SeiglerReva CrandallJeffrey ThomasCaralee ForseenKathleen T McKieRyan A Harris

Published in: Therapeutic advances in chronic disease (2019)

This proof-of-concept clinical trial demonstrates that sildenafil treatment can improve exercise capacity in patients with CF and that pulmonary function may play an important role in the effectiveness of treatment. Future investigations of sildenafil treatment in patients with CF are certainly warranted.

Keyphrases

clinical trial
cystic fibrosis
end stage renal disease
systematic review
randomized controlled trial
pulmonary arterial hypertension
high intensity
physical activity
chronic kidney disease
combination therapy
open label
prognostic factors