Antibiotic treatment of bacterial vaginosis to prevent preterm delivery: Systematic review and individual participant data meta-analysis.
Mark A KlebanoffEwoud SchuitRonald F LamontPer-Göran LarssonHein J OdendaalAustin UgwumaduHerbert KissLjubomir PetricevicWilliam W AndrewsMatthew K HoffmanAndrew ShennanPaul T SeedRobert L GoldenbergLynda M EmelVinay BhandaruSteven WeinerMichael D LarsenPublished in: Paediatric and perinatal epidemiology (2023)
Clindamycin, but not metronidazole, was beneficial in studies providing IPD, but after imputing data from missing IPD studies, treatment of BV during pregnancy did not reduce PTD, nor prolong pregnancy, in any subgroup or when started earlier in gestation.
Keyphrases
- systematic review
- meta analyses
- case control
- electronic health record
- preterm birth
- randomized controlled trial
- preterm infants
- big data
- pregnant women
- gestational age
- clinical trial
- inflammatory response
- combination therapy
- machine learning
- low birth weight
- lps induced
- artificial intelligence
- deep learning
- double blind
- placebo controlled