Efficacy of Different Modalities and Frequencies of Physical Exercise on Glucose Control in People with Prediabetes (GLYCEX Randomised Trial).
Aina Maria Galmes-PanadesMiquel Bennasar VenyPaula OliverNatalia Garcia-CollAlice ChaplinSergio FresnedaLaura Gallardo-AlfaroCarmen García-RuanoJadwiga KoniecznaAlfonso LeivaLluis MasmiquelCatalina PicóIgnacio Ricci-CabelloDora RomagueraRosmeri RiveraPilar SanchisJosep Vidal-ContiAina Maria Yañez JuanPublished in: Metabolites (2022)
To assess the efficacy of different modalities and frequencies of physical exercise on glycaemic control in adults with prediabetes. A two-phase, parallel, randomised, controlled clinical trial will be carried out, in 210 participants. In phase 1, 120 participants will be randomized into four arms: (1) aerobic exercise, (2) aerobic exercise combined with resistance, (3) high-intensity intervallic exercise and (4) control group. In phase 2, 90 new participants will be randomized into three arms, using the exercise modality that showed the best glycaemic control in phase 1 in the following manner: (1) frequency of 5 days/week, (2) frequency of 3 days/week and (3) frequency of 2 days/week. The control group (n = 30) will be included in phase 1 to evaluate the effect of any type of intervention versus no intervention. Data collection will be performed at baseline and after 15 weeks of follow up. Sociodemographic data, medication, comorbidity, blood biochemical parameters, blood pressure, anthropometric measurements, body composition, physical activity, sedentary lifestyle, diet, smoking, alcohol consumption, quality of life and sleep questionnaires will be collected. Physical activity, sedentary behaviour and sleep will be further determined with an accelerometer, and continuous glycaemia will be determined with a glycaemic monitor, both during seven days, at two time points. The main dependent variable will be the reduction in the mean amplitude of glycaemic excursions. The impact of these interventions on health will also be evaluated through gene expression analysis in peripheral blood cells. The results of this study will contribute to a better understanding of the mechanisms behind the glucose response to physical exercise in a population with prediabetes as well as improve physical exercise prescriptions for diabetes prevention. Increasing glycaemic control in people with prediabetes through physical exercise offers an opportunity to prevent diabetes and reduce associated comorbidities and health costs.
Keyphrases
- physical activity
- type diabetes
- high intensity
- body composition
- clinical trial
- resistance training
- blood pressure
- placebo controlled
- double blind
- healthcare
- open label
- body mass index
- randomized controlled trial
- public health
- alcohol consumption
- peripheral blood
- mental health
- sleep quality
- emergency department
- depressive symptoms
- phase ii
- electronic health record
- metabolic syndrome
- blood glucose
- oxidative stress
- deep learning
- adipose tissue
- induced apoptosis
- study protocol
- weight loss
- skeletal muscle
- machine learning
- transcription factor
- genome wide identification
- dna methylation
- health promotion
- human health
- copy number
- resting state
- risk assessment