Impact of anti-epileptic drug choice on discharge in acute traumatic brain injury patients.
Lauren HarrisSofie HateleyK T TsangM WilsonB M SeemungalPublished in: Journal of neurology (2020)
In this cohort, using Phenytoin for acute TBI, seizure prophylaxis was associated with longer length of stay and more dizziness compared to Levetiracetam. Given their equivalent AED efficacy in acute TBI seizure prophylaxis, our data suggest that Levetiracetam is preferable to Phenytoin for early seizure prophylaxis in TBI. This requires evaluation in larger, prospective studies.
Keyphrases
- traumatic brain injury
- liver failure
- respiratory failure
- drug induced
- severe traumatic brain injury
- end stage renal disease
- aortic dissection
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- temporal lobe epilepsy
- peritoneal dialysis
- mild traumatic brain injury
- emergency department
- intensive care unit
- machine learning
- deep learning
- mechanical ventilation
- data analysis