Regional Differences in Human Biliary Tissues and Corresponding In Vitro-Derived Organoids.
Casey A RimlandSamantha G TilsonCarola M MorellRute A TomazWei-Yu LuSimone E AdamsNikitas GeorgakopoulosFrancisco Otaizo-CarrasqueroTimothy G MyersJohn R FerdinandRichard L GieseckFotios SampaziotisOlivia C TysoeAlexander RossJudith M KraiczyBrandon WesleyDaniele MuraroMatthias ZilbauerGabriel C OniscuNicholas R F HannanStuart John ForbesKourosh Saeb-ParsyThomas A WynnLudovic VallierPublished in: Hepatology (Baltimore, Md.) (2021)
Taken together, our results demonstrate that differences exist not only between extrahepatic biliary organoids and their tissue of origin, but also between IHBD and EHBD organoids. This information may help to understand the tissue specificity of cholangiopathies and also to identify targets for therapeutic development.