Co-expression of drug metabolizing cytochrome P450 enzymes and estrogen receptor alpha (ESR1) in human liver: racial differences and the regulatory role of ESR1.

Published in: Drug metabolism and personalized therapy (2021)

These results are consistent with our previous study showing ESR1 as a master regulator for the expression of several CYP enzymes. Therefore, factors affecting ESR1 expression may have broad influence on drug metabolism through altered expression of CYP enzymes.

Keyphrases

estrogen receptor
poor prognosis
binding protein
transcription factor
long non coding rna
adverse drug
drug induced