Intraoperative germinoma staining: a technical note.

As the main treatment modality of central neural system germinomas is radio- and/or chemotherapy, the exact initial diagnosis of the disease is crucial. Depending on the different national protocols, in some instances the histological verification can be obligatory. This is a serious challenge, taking into account the usual location and non-specific macroscopic appearance of these lesions. Here, we propose a safe and effective method of intraoperative tumor enhancement which can increase the confidence of the surgeon during the intervention.