Interferon regulatory factor 1 (IRF1) controls the metabolic programmes of low-grade pancreatic cancer cells.

Gabriele AlfaranoMatteo AudanoPierluigi Di ChiaroChiara BalestrieriMarta MilanSara PollettiPaola SpaggiariAlessandro ZerbiGiuseppe Riccardo DiaferiaNico MitroGioacchino Natoli

Published in: Gut (2022)

IRF1 links endodermal differentiation to the expression of genes controlling antigen presentation and processing as well as to the specification of the metabolic profile characteristic of classical PDAC cells.

Keyphrases

low grade
dendritic cells
high grade
induced apoptosis
poor prognosis
cell cycle arrest
genome wide
transcription factor
immune response
dna methylation
case report
gene expression
cell death
long non coding rna
cell proliferation
bioinformatics analysis
genome wide identification