Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis.
Marina O RontogianniEmmanouil BourasElom Kouassivi AglagoHeinz FreislingNeil MurphyMichelle CotterchioJochen HampeAnnika LindblomRish K PaiPaul David Peter PharoahAmanda I PhippsFranzel J B van DuijnhovenKala VisvanathanBethany van GuelpenChristopher I LiHermann BrennerAndrew J PellattShuji OginoMarc J GunterUlrike PetersSofia ChristakoudiKonstantinos K TsilidisPublished in: International journal of obesity (2005) (2024)
This large MR study provides strong evidence for a potential causal positive association of the allometric indices ABSI and WHI with CRC in both sexes, thus establishing the association between abdominal fat and CRC without the limitations of the traditional waist size indices and independently of BMI. Among the BMI-adjusted traditional indices, WHR and HC provided equivalent associations with WHI and HI, while differences were observed between WC and ABSI.