Arginase-1 Deletion in Erythrocytes Promotes Vascular Calcification via Enhanced GSNOR (S-Nitrosoglutathione Reductase) Expression and NO Signaling in Smooth Muscle Cells.
Rajinikanth GogirajuLuisa RennerMagdalena L BochenekKonstantinos ZifkosMichael MolitorSven DanckwardtPhilip WenzelThomas MunzelStavros V KonstantinidesKatrin SchäferPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Our findings support an important role of erythrocyte ARG1 for NO bioavailability and L-arginine metabolism in VSMCs, which controls atherosclerotic lesion composition and calcification.