Malignant development of proliferative verrucous/multifocal leukoplakia: A critical systematic review, meta-analysis and proposal of diagnostic criteria.

Irene Lafuente-Ibáñez de Mendoza Alejandro Ismael Lorenzo-Pouso José Manuel Aguirre-UrizarCatalina Barba MonteroAndrés Blanco CarriónPilar Gándara VilaMário Pérez-Sayáns

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2021)

The pooled MD of PVML was 65.8% (95% CI: 55.3-76.2, p < 0.001). Prospective studies of PVML must be designed using simple and universal clinical diagnostic criteria to be able to make an early diagnosis of this important OPMD and acknowledge the frequency of MD.

Keyphrases

systematic review
meta analyses
molecular dynamics
case control
randomized controlled trial
open label