Prenatal alcohol exposure contributes to negative pregnancy outcomes by altering fetal vascular dynamics and the placental transcriptome.

Marisa R PinsonAlexander M TsengAmy AdamsTenley E LehmanKaren ChungJessica GutierrezKirill V LarinChristina D Chambers Rajesh C Mirandanull null

Published in: Alcoholism, clinical and experimental research (2022)

Our data suggest that PAE perturbs the expression of placental genes relevant for placental hematopoiesis and environmental sensing, resulting in transient impairment of umbilical cord blood flow and, subsequently, IUGR.

Keyphrases

blood flow
umbilical cord
pregnancy outcomes
mesenchymal stem cells
pregnant women
genome wide
poor prognosis
gene expression
electronic health record
rna seq
single cell
bone marrow
dna methylation
human health
brain injury
alcohol consumption
transcription factor
deep learning
genome wide identification