Traumatic occlusion aggravates bone loss during periodontitis and activates Hippo-YAP pathway.

Weiyi PanLi YangJinle LiLili XueWei WeiHandong DingShibing DengYe TianYuan YueMin WangLiang HaoQianming Chen

Published in: Journal of clinical periodontology (2019)

Our study demonstrated that periodontitis with TO caused severe inflammation-induced bone resorption. Activation of YAP and upregulation of JNK/AP-1 induced by TO potentially aggravated the symptoms of PD.

Keyphrases

bone loss
signaling pathway
oxidative stress
spinal cord injury
drug induced
diabetic rats
poor prognosis
cell death
transcription factor
high glucose
cell proliferation
induced apoptosis
bone mineral density
long non coding rna
sleep quality
soft tissue
endoplasmic reticulum stress