Inhibitory effect of alpinetin on IL-6 expression by promoting cytosine methylation in CpG islands in the IL-6 promoter region.

Ke Hu Yuxian Li Minghua Liang Lijing Liu Yuefu Chen Minjiang Huang Bifeng Tan Yingquan Luo Huiming Yin

Published in: Molecular genetics & genomic medicine (2019)

Alpinetin could induce dinucleotide methylation status of CpG islands in the IL-6 promoter region by activating methyltransferase, thus inhibiting IL-6 expression in murine macrophages.

Keyphrases

dna methylation
poor prognosis
genome wide
signaling pathway
transcription factor
binding protein