Palladium-Catalyzed [3 + 2] Annulation of ortho- Substituted Iodoarenes with Maleimides via a Consecutive Double Heck-type Strategy.

Herein, we report an efficient [3 + 2] annulation of ortho -substituted iodoarenes with maleimides via a palladium-catalyzed consecutive double Heck-type strategy, leading to fused tricyclic frameworks of pharmaceutical relevance. The protocol ensued through consecutive inter- and intramolecular Heck couplings effectively. This approach was compatible with a large variety of substrates and functional groups, and it was remarkably tolerated with unprotected maleimide.