Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1.

Xiangliang YuanYimin DuanYi XiaoKai SunYutao QiYuan ZhangZamal AhmedDavide MoianiYao JunHongzhong LiLin ZhangArseniy E YuzhalinPing LiChenyu ZhangAkosua Badu-NkansahYohei SaitoXianghua LiuWen-Ling KuoHaoqiang YingShao-Cong SunJenny C ChangJohn A Tainer Dihua Yu

Published in: Cancer discovery (2022)

The impacts of nutritional supplements on responses to immunotherapies remain unexplored. Our study revealed that dietary vitamin E binds to and inhibits DC checkpoint SHP1 to increase antigen presentation, prime antitumor T-cell immunity, and enhance immunotherapy efficacy. VitE-treated or SHP1-silenced DCs/DC-EVs could be developed as potent immunotherapies. This article is highlighted in the In This Issue feature, p. 1599.

Keyphrases

dendritic cells
dna damage
cell cycle
immune response
regulatory t cells
machine learning
single cell
cancer therapy
cell proliferation