John A Tainer

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 51

Top Topics

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Nature communications

Nature chemical biology

Nucleic acids research

This page only lists publications with an associated author ORCID identifier.

Publications

Chandrima Das, Apoorva Bhattacharya, Swagata Adhikari, Atanu Mondal, Payel Mondal, Santanu Adhikary, Siddhartha Roy, Kenneth Ramos, Kamlesh K Yadav, John A Tainer, Tej K Pandita
A prismatic view of the epigenetic-metabolic regulatory axis in breast cancer therapy resistance. Oncogene 43 (23) (2024)
Chris A Brosey, Todd M Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L Hura, Darin E Jones, John A Tainer
Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nature chemical biology 20 (9) (2024)
Chandrima Das, Apoorva Bhattacharya, Swagata Adhikari, Atanu Mondal, Payel Mondal, Santanu Adhikary, Siddhartha Roy, Kenneth Ramos, Kamlesh K Yadav, John A Tainer, Tej K Pandita
A prismatic view of the epigenetic-metabolic regulatory axis in breast cancer therapy resistance. Oncogene (2024)
Zu Ye, Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy, Sarita Namjoshi, Michael A Longo, Todd M Link, Katharina Schlacher, Guang Peng, Dihua Yu, Bin Wang, John A Tainer, Zamal Ahmed
GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nature communications 15 (1) (2024)
Zu Ye, Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy, Sarita Namjoshi, Michael A Longo, Todd M Link, Katharina Schlacher, Guang Peng, Dihua Yu, Bin Wang, John A Tainer, Zamal Ahmed
GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nature communications 15 (1) (2024)
Chris A Brosey, Todd M Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L Hura, Darin E Jones, John A Tainer
Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nature chemical biology (2024)
Chandrima Das, Apoorva Bhattacharya, Swagata Adhikari, Atanu Mondal, Payel Mondal, Santanu Adhikary, Siddhartha Roy, Kenneth Ramos, Kamlesh K Yadav, John A Tainer, Tej K Pandita
A prismatic view of the epigenetic-metabolic regulatory axis in breast cancer therapy resistance. Oncogene 43 (23) (2024)
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nature communications 15 (1) (2024)
Chris A Brosey, Todd M Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L Hura, Darin E Jones, John A Tainer
Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nature chemical biology 20 (9) (2024)
Ryan L Woltz, Brandon D Schweibenz, Susan E Tsutakawa, Chen Zhao, LiChung Ma, Ben Shurina, Gregory L Hura, Rachael John, Sergey Vorobiev, Gurla V T Swapna, Mihai Solotchi, John A Tainer, Robert M Krug, Smita S Patel, Gaetano T Montelione
The NS1 protein of influenza B virus binds 5'-triphosphorylated dsRNA to suppress RIG-I activation and the host antiviral response. bioRxiv : the preprint server for biology (2024)
Chris A Brosey, Todd M Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L Hura, Darin E Jones, John A Tainer
Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nature chemical biology (2024)
Ryan L Woltz, Brandon D Schweibenz, Susan E Tsutakawa, Chen Zhao, LiChung Ma, Ben Shurina, Gregory L Hura, Rachael John, Sergey Vorobiev, Gurla V T Swapna, Mihai Solotchi, John A Tainer, Robert M Krug, Smita S Patel, Gaetano T Montelione
The NS1 protein of influenza B virus binds 5'-triphosphorylated dsRNA to suppress RIG-I activation and the host antiviral response. bioRxiv : the preprint server for biology (2024)
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nature communications 15 (1) (2024)
Ryan L Woltz, Brandon D Schweibenz, Susan E Tsutakawa, Chen Zhao, LiChung Ma, Ben Shurina, Gregory L Hura, Rachael John, Sergey Vorobiev, Gurla V T Swapna, Mihai Solotchi, John A Tainer, Robert M Krug, Smita S Patel, Gaetano T Montelione
The NS1 protein of influenza B virus binds 5'-triphosphorylated dsRNA to suppress RIG-I activation and the host antiviral response. bioRxiv : the preprint server for biology (2024)
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nature communications 15 (1) (2024)
Zu Ye, Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy, Sarita Namjoshi, Michael A Longo, Todd M Link, Katharina Schlacher, Guang Peng, Dihua Yu, Bin Wang, John A Tainer, Zamal Ahmed
GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nature communications 15 (1) (2024)
Chris A Brosey, Todd M Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L Hura, Darin E Jones, John A Tainer
Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nature chemical biology 20 (9) (2024)
Chris A Brosey, Todd M Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L Hura, Darin E Jones, John A Tainer
Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nature chemical biology 20 (9) (2024)
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nature communications 15 (1) (2024)
Chandrima Das, Apoorva Bhattacharya, Swagata Adhikari, Atanu Mondal, Payel Mondal, Santanu Adhikary, Siddhartha Roy, Kenneth Ramos, Kamlesh K Yadav, John A Tainer, Tej K Pandita
A prismatic view of the epigenetic-metabolic regulatory axis in breast cancer therapy resistance. Oncogene 43 (23) (2024)
Chandrima Das, Apoorva Bhattacharya, Swagata Adhikari, Atanu Mondal, Payel Mondal, Santanu Adhikary, Siddhartha Roy, Kenneth Ramos, Kamlesh K Yadav, John A Tainer, Tej K Pandita
A prismatic view of the epigenetic-metabolic regulatory axis in breast cancer therapy resistance. Oncogene 43 (23) (2024)
Zu Ye, Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy, Sarita Namjoshi, Michael A Longo, Todd M Link, Katharina Schlacher, Guang Peng, Dihua Yu, Bin Wang, John A Tainer, Zamal Ahmed
GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nature communications 15 (1) (2024)
Zu Ye, Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy, Sarita Namjoshi, Michael A Longo, Todd M Link, Katharina Schlacher, Guang Peng, Dihua Yu, Bin Wang, John A Tainer, Zamal Ahmed
GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nature communications 15 (1) (2024)
Chris A Brosey, Todd M Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L Hura, Darin E Jones, John A Tainer
Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nature chemical biology (2024)
Jie Fu, Jianhua Ling, Ching-Fei Li, Chi-Lin Tsai, Wenjuan Yin, Junwei Hou, Ping Chen, Yu Cao, Ya'an Kang, Yichen Sun, Xianghou Xia, Zhou Jiang, Kenei Furukawa, Yu Lu, Min Wu, Qian Huang, Jun Yao, David H Hawke, Bih-Fang Pan, Jun Zhao, Jiaxing Huang, Huamin Wang, E I Mustapha Bahassi, Peter J Stambrook, Peng Huang, Jason B Fleming, Anirban Maitra, John A Tainer, Mien-Chie Hung, Chunru Lin, Paul J Chiao
Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nature communications 15 (1) (2024)
Chris A Brosey, Todd M Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L Hura, Darin E Jones, John A Tainer
Chemical screening by time-resolved X-ray scattering to discover allosteric probes. Nature chemical biology (2024)
Aleem Syed, Frantisek Filandr, Jeffrey Patterson-Fortin, Albino Bacolla, Ramya Ravindranathan, Jia Zhou, Drew T McDonald, Mohammed E Albuhluli, Amy Verway-Cohen, Joseph A Newman, Miaw-Sheue Tsai, Darin E Jones, David C Schriemer, Alan D D'Andrea, John A Tainer
Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity. Nucleic acids research (2023)
Chandrima Das, Swagata Adhikari, Apoorva Bhattacharya, Sanjukta Chakraborty, Payel Mondal, Shalini Singh Yadav, Santanu Adhikary, Clayton R Hunt, Kamlesh K Yadav, Shruti Pandita, Siddhartha Roy, John A Tainer, Zamal Ahmed, Tej K Pandita
Epigenetic-Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer. Cancer research (2023)
Chandrima Das, Swagata Adhikari, Apoorva Bhattacharya, Sanjukta Chakraborty, Payel Mondal, Shalini Singh Yadav, Santanu Adhikary, Clayton R Hunt, Kamlesh K Yadav, Shruti Pandita, Siddhartha Roy, John A Tainer, Zamal Ahmed, Tej K Pandita
Epigenetic-Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer. Cancer research 83 (5) (2023)
Chandrima Das, Swagata Adhikari, Apoorva Bhattacharya, Sanjukta Chakraborty, Payel Mondal, Shalini Singh Yadav, Santanu Adhikary, Clayton R Hunt, Kamlesh K Yadav, Shruti Pandita, Siddhartha Roy, John A Tainer, Zamal Ahmed, Tej K Pandita
Epigenetic-Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer. Cancer research 83 (5) (2023)
Michael A Longo, Sunetra Roy, Yue Chen, Karl-Heinz Tomaszowski, Andrew S Arvai, Jordan T Pepper, Rebecca A Boisvert, Selvi Kunnimalaiyaan, Caezanne Keshvani, David Schild, Albino Bacolla, Gareth J Williams, John A Tainer, Katharina Schlacher
RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles. Nature communications 14 (1) (2023)
Shyam Twayana, Albino Bacolla, Angelica Barreto-Galvez, Ruth B De-Paula, William C Drosopoulos, Settapong T Kosiyatrakul, Eric E Bouhassira, John A Tainer, Advaitha Madireddy, Carl L Schildkraut
Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites. Proceedings of the National Academy of Sciences of the United States of America 118 (48) (2022)
Amer Bralić, Muhammad Tehseen, Mohamed A Sobhy, Chi-Lin Tsai, Lubna Alhudhali, Gang Yi, Jina Yu, Chunli Yan, Ivaylo Ivanov, Susan E Tsutakawa, John A Tainer, Samir M Hamdan
A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair. Nucleic acids research (2022)
Mihyun Kim, Hyun-Suk Kim, Areetha D'Souza, Kaitlyn Gallagher, Eunwoo Jeong, Agnieszka Topolska-Wós, Kateryna Ogorodnik Le Meur, Chi-Lin Tsai, Miaw-Sheue Tsai, Minyong Kee, John A Tainer, Jung-Eun Yeo, Walter Jacob Chazin, Orlando D Schärer
Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair. Proceedings of the National Academy of Sciences of the United States of America 119 (34) (2022)
Xiangliang Yuan, Yimin Duan, Yi Xiao, Kai Sun, Yutao Qi, Yuan Zhang, Zamal Ahmed, Davide Moiani, Yao Jun, Hongzhong Li, Lin Zhang, Arseniy E Yuzhalin, Ping Li, Chenyu Zhang, Akosua Badu-Nkansah, Yohei Saito, Xianghua Liu, Wen-Ling Kuo, Haoqiang Ying, Shao-Cong Sun, Jenny C Chang, John A Tainer, Dihua Yu
Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1. Cancer discovery 12 (7) (2022)
Hou-Fu Guo, Maria Neus Bota Rabassedas, Masahiko Terajima, B Leticia Rodriguez, Don L Gibbons, Yulong Chen, Priyam Banerjee, Chi-Lin Tsai, Xiaochao Tan, Xin Liu, Jiang Yu, Michal Tokmina-Roszyk, Roma Stawikowska, Gregg B Fields, Mitchell D Miller, Xiaoyan Wang, Juhoon Lee, Kevin N Dalby, Chad J Creighton, George N Philips, John A Tainer, Mitsuo Yamauchi, Jonathan M Kurie
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice. Communications biology 4 (1) (2021)
Zu Ye, Shengfeng Xu, Yin Shi, Albino Bacolla, Aleem Syed, Davide Moiani, Chi-Lin Tsai, Qiang Shen, Guang Peng, Paul G Leonard, Darin E Jones, Bin Wang, John A Tainer, Zamal Ahmed
GRB2 enforces homology-directed repair initiation by MRE11. Science advances 7 (32) (2021)
Michal Hammel, John A Tainer
X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology. Protein science : a publication of the Protein Society 30 (9) (2021)
Susan E Tsutakawa, Altaf H Sarker, Clifford Ng, Andrew S Arvai, David S Shin, Brian Shih, Shuai Jiang, Aye C Thwin, Miaw-Sheue Tsai, Alexandra Willcox, Mai Zong Her, Kelly S Trego, Alan G Raetz, Daniel J Rosenberg, Albino Bacolla, Michal Hammel, Jack D Griffith, Priscilla K Cooper, John A Tainer
Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations. Proceedings of the National Academy of Sciences of the United States of America 117 (25) (2020)
Jerry H Houl, Zu Ye, Chris A Brosey, Lakshitha P F Balapiti-Modarage, Sarita Namjoshi, Albino Bacolla, Daniel Laverty, Brian L Walker, Yasin Pourfarjam, Leslie S Warden, Naga Babu Chinnam, Davide Moiani, Roderick A Stegeman, Mei-Kuang Chen, Mien-Chie Hung, Zachary D Nagel, Tom Ellenberger, In-Kwon Kim, Darin E Jones, Zamal Ahmed, John A Tainer
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nature communications 10 (1) (2019)
Chunli Yan, Thomas Dodd, Yuan He, John A Tainer, Susan E Tsutakawa, Ivaylo Ivanov
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases. Nature structural & molecular biology 26 (6) (2019)
Chi-Lin Tsai, Patrick Tripp, Shamphavi Sivabalasarma, Changyi Zhang, Marta Rodriguez-Franco, Rebecca L Wipfler, Paushali Chaudhury, Ankan Banerjee, Morgan Beeby, Rachel J Whitaker, John A Tainer, Sonja-Verena Albers
The structure of the periplasmic FlaG-FlaF complex and its essential role for archaellar swimming motility. Nature microbiology 5 (1) (2019)
Greg L Hura, Curtis D Hodge, Daniel Rosenberg, Dmytro Guzenko, Jose M Duarte, Bohdan Monastyrskyy, Sergei Grudinin, Andriy Kryshtafovych, John A Tainer, Krzysztof Fidelis, Susan E Tsutakawa
Small angle X-ray scattering-assisted protein structure prediction in CASP13 and emergence of solution structure differences. Proteins 87 (12) (2019)
Hou-Fu Guo, Chi-Lin Tsai, Masahiko Terajima, Xiaochao Tan, Priyam Banerjee, Mitchell D Miller, Xin Liu, Jiang Yu, Jovita Byemerwa, Sarah Alvarado, Tamer S Kaoud, Kevin N Dalby, Neus Bota-Rabassedas, Yulong Chen, Mitsuo Yamauchi, John A Tainer, George N Phillips, Jonathan M Kurie
Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding. Nature communications 9 (1) (2018)
Roopa Thapar, Albino Bacolla, Clement Oyeniran, Joshua R Brickner, Naga Babu Chinnam, Nima Mosammaparast, John A Tainer
RNA Modifications: Reversal Mechanisms and Cancer. Biochemistry 58 (5) (2018)
Jing L Wang, Camille Duboc, Qian Wu, Takashi Ochi, Shikang Liang, Susan E Tsutakawa, Susan P Lees-Miller, Marc Nadal, John A Tainer, Thomas L Blundell, Terence R Strick
Dissection of DNA double-strand-break repair using novel single-molecule forceps. Nature structural & molecular biology 25 (6) (2018)
Henry Y H Tang, David S Shin, Greg L Hura, Yue Yang, Xiaoyu Hu, Felice C Lightstone, Matthew D McGee, Hal S Padgett, Steven M Yannone, John A Tainer
Structural Control of Nonnative Ligand Binding in Engineered Mutants of Phosphoenolpyruvate Carboxykinase. Biochemistry 57 (48) (2018)
Hou-Fu Guo, Chi-Lin Tsai, Masahiko Terajima, Xiaochao Tan, Priyam Banerjee, Mitchell D Miller, Xin Liu, Jiang Yu, Jovita Byemerwa, Sarah Alvarado, Tamer S Kaoud, Kevin N Dalby, Neus Bota-Rabassedas, Yulong Chen, Mitsuo Yamauchi, John A Tainer, George N Phillips, Jonathan M Kurie
Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding. Nature communications 9 (1) (2018)
Susan E Tsutakawa, Mark J Thompson, Andrew S Arvai, Alexander J Neil, Steven J Shaw, Sana I Algasaier, Jane C Kim, L David Finger, Emma Jardine, Victoria J B Gotham, Altaf H Sarker, Mai Z Her, Fahad Rashid, Samir M Hamdan, Sergei M Mirkin, Jane A Grasby, John A Tainer
Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability. Nature communications 8 (2017)
Albino Bacolla, John A Tainer, Karen M Vasquez, David N Cooper
Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences. Nucleic acids research 44 (12) (2016)
Yen-Ting Lai, Greg L Hura, Kevin N Dyer, Henry Y H Tang, John A Tainer, Todd O Yeates
Designing and defining dynamic protein cage nanoassemblies in solution. Science advances 2 (12) (2016)