Vasoactive intestinal peptide ameliorates renal injury in a pristane-induced lupus mouse model by modulating Th17/Treg balance.

Dongdong FuSoulixay SenouthaiJunjie WangYan-Wu You

Published in: BMC nephrology (2019)

VIP reduced LN proteinuria and renal function defects and restored the Th17/Treg cell balance. Furthermore, VIP also downregulated autoantibody and inflammatory cytokine expression and upregulated Foxp3 and IL-10 expression.

Keyphrases

mouse model
poor prognosis
systemic lupus erythematosus
regulatory t cells
binding protein
single cell
signaling pathway
high glucose
stem cells
long non coding rna
cell therapy
diabetic rats
mesenchymal stem cells
immune response
endothelial cells