Hypoxia and inflammation conditions differentially affect the expression of tissue transglutaminase spliced variants and functional properties of extravillous trophoblast cells.

Paula ArbildiClaudio Rodríguez-CamejoKaren PerelmuterMariela Bollati-FogolínCecilia SóñoraAna Hernández

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2022)

The observed decrease in total TG2 expression and relative increase in short variants under hypoxia conditions could contribute to impaired trophoblast invasion and impact on pregnancy outcome.

Keyphrases

poor prognosis
copy number
induced apoptosis
oxidative stress
cell cycle arrest
binding protein
long non coding rna
gene expression
signaling pathway
celiac disease