Efficacy and safety of VEGFR inhibitors for recurrent ovarian cancer: a systematic review.
Linlin TanYuchun NiZhaowei HuangJiaqi YanMei WuZhipeng ZhangFupeng ZhangZhi-Jie WangPublished in: Future oncology (London, England) (2024)
Aim: Vascular endothelial growth factor receptor inhibitors (VEGFRIs) have been common used for recurrent ovarian cancer (ROC), but insufficient high-level evidence on verifying its efficacy and safety. Methods: Randomized controlled trials (RCTs) were searched under eight electronic databases. Stata 14.0 and Review Manager 5.3 were used for data analysis. Certainty of the evidence was assessed using the GRADE profiler. This systematic review (SR) was registered under INPLASY (INPLASY202120019). Conclusion: Totally 23 RCTs involving 2810 patients were included in this SR. Current evidence revealed that VEGFRIs had better efficacy, survival and quality of life in the treatment of ROC. Though VEGFRIs increase some drug-related adverse events (AEs), all the AEs could be manageable in the clinical practice.
Keyphrases
- vascular endothelial growth factor
- data analysis
- systematic review
- end stage renal disease
- clinical practice
- meta analyses
- randomized controlled trial
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- emergency department
- clinical trial
- machine learning
- single cell
- adverse drug
- binding protein
- replacement therapy