The Weighted Toxicity Score: Confirmation of a Simple Metric to Communicate Toxicity in Randomized Trials of Systemic Cancer Therapy.
Jacob JordanRobert G MakiPublished in: The oncologist (2023)
The WTS provides a tool to show the cost in toxicity of therapy in a randomized clinical trial, with applicability to studies involving chemotherapy, immunotherapy, or kinase-directed therapy. Inclusion of a running tally of WTS during conduct of a trial could serve as one means to adjust dosing or to provide feedback during data safety monitoring of a clinical trial.
Keyphrases
- clinical trial
- cancer therapy
- oxidative stress
- phase iii
- phase ii
- study protocol
- magnetic resonance
- drug delivery
- electronic health record
- randomized controlled trial
- stem cells
- computed tomography
- squamous cell carcinoma
- tyrosine kinase
- high intensity
- cell therapy
- protein kinase
- bone marrow
- network analysis
- drug induced