Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery.
Gianfranco DecandiaFabio PalumboAnnalisa TregliaVincenza ArmenisePietro FaviaFederico BaruzziKatrin UngerAlberto PerrottaAnna Maria CoclitePublished in: Pharmaceutics (2020)
A coating consisting of a copolymer of methacrylic acid and ethylene glycol dimethacrylate was deposited over a gentamicin film by initiated chemical vapor deposition with the aim of controlling the drug release. Gentamicin release in water was monitored by means of conductance measurements and of UV-vis Fluorescence Spectroscopy. The influence of the polymer chemical composition, specifically of its crosslinking density, has been investigated as a tool to control the swelling behavior of the initiated chemical vapor deposition (iCVD) coating in water, and therefore its ability to release the drug. Agar diffusion test and microbroth dilution assays against Staphylococcus aureus and Pseudomonas aeruginosa on cellulose coated substrates confirmed that the antibacterial activity of the drug released by the coating was retained, though the release of gentamicin was not complete.
Keyphrases
- drug release
- pseudomonas aeruginosa
- staphylococcus aureus
- drug delivery
- single molecule
- biofilm formation
- cystic fibrosis
- high resolution
- emergency department
- silver nanoparticles
- adverse drug
- room temperature
- drug induced
- reduced graphene oxide
- atomic force microscopy
- acinetobacter baumannii
- methicillin resistant staphylococcus aureus