Phylogenetic Cluster Analysis Identifies Virological and Behavioral Drivers of Human Immunodeficiency Virus Transmission in Men Who Have Sex With Men.

Nadine TschumiKatharina KusejkoHuyen NguyenSandra E ChaudronClaus KadelkaTeja TurkJürg BöniMatthieu PerreauThomas KlimkaitSabine YerlyManuel BattegayAndri RauchAlban RamettePietro VernazzaEnos BernasconiMatthias CavassiniHuldrych F GünthardRoger D Kouyosnull null

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

We present a phylogenetic method to identify hotspots of ongoing transmission among MSM. Our results demonstrate the effectiveness of treatment as prevention at the population level. However, the significantly increasing number of new infections among transmission clusters without infectious members highlights a relative shift from diagnosed to undiagnosed individuals as drivers of HIV transmission in Swiss MSM.

Keyphrases

men who have sex with men
hiv testing
hiv positive
human immunodeficiency virus
antiretroviral therapy
hiv infected
hepatitis c virus
systematic review
hiv aids
hiv infected patients
randomized controlled trial
gene expression
south africa
smoking cessation