Activated AMP-protein kinase (pAMPK) is overexpressed in human somatotroph pituitary adenomas.
Mariana Ferreira BizziJuliana Beaudette DrummondSergio Veloso Brant PinheiroEduardo PaulinoStanley Almeida AraújoBeatriz Santana SoaresAlexandre V GiannettiJúnia Ribeiro de Oliveira Longo SchweizerSayka BarryMárta KorbonitsAntonio Ribeiro-OliveiraPublished in: Molecular and cellular endocrinology (2024)
Our data show, for the first time in human cells, an increase of cellular levels of pAMPK in sporadic somatotropinomas, regardless of cytokeratin pattern, as well as in GH-secreting adenomas from patients with germline AIP mutations.