Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease.
Johanna DahlqvistCharles P FulcoJohn P RayThomas LiechtiCarl G de BoerDavid J LiebThomas M EisenhaureJesse M EngreitzMario RoedererNir HacohenPublished in: Human molecular genetics (2022)
The FCGR2A gene is regulated by multiple proximal and distal genomic regions, with links to autoimmune disease. These findings may open up novel therapeutic avenues where fine-tuning of FCGR2A levels may constitute a part of treatment strategies for immune-mediated diseases.