Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease.

Johanna DahlqvistCharles P FulcoJohn P RayThomas LiechtiCarl G de BoerDavid J LiebThomas M EisenhaureJesse M EngreitzMario RoedererNir Hacohen

Published in: Human molecular genetics (2022)

The FCGR2A gene is regulated by multiple proximal and distal genomic regions, with links to autoimmune disease. These findings may open up novel therapeutic avenues where fine-tuning of FCGR2A levels may constitute a part of treatment strategies for immune-mediated diseases.

Keyphrases

copy number
minimally invasive
multiple sclerosis
poor prognosis
air pollution
gene expression
drug induced
dna methylation
binding protein
transcription factor
long non coding rna