DNA methyltransferase expression (DNMT1, DNMT3a and DNMT3b) as a potential biomarker for anti-VEGF diabetic macular edema response.

Pedro CamachoEdna RibeiroBruno PereiraTeresa VarandasJoão NascimentoJosé HenriquesMarco Dutra-MedeirosMariana DelgadinhoKetlyn OliveiraCarina SilvaMiguel Brito

Published in: European journal of ophthalmology (2023)

Patients with similar metabolic profile risk factors showed associated DNA methyltransferase transcriptional expression patterns differences fitting with the anti-VEGF diabetic macular edema response. Further studies are needed to clarify if these results (1) reflect disease evolution, (2) translate the therapeutic impact, (3) or can help to predict the therapeutic resistance profile.

Keyphrases

dna methylation
poor prognosis
risk factors
circulating tumor
vascular endothelial growth factor
endothelial cells
cell free
single molecule
binding protein
gene expression
long non coding rna
oxidative stress