[Detection of paraprotein in plasma cell tumors].
I G RekhtinaL P MendeleyevaN P SobolevaI A DubinaMargarita Y PervakovaSergey V LapinPublished in: Terapevticheskii arkhiv (2022)
Paraprotein is a laboratory biomarker of plasma cell tumors and other lymphoproliferative diseases. Its determination is necessary for diagnosing, monitoring and assessment of therapy effectiveness. The lecture presents the main methods of qualitative and quantative analysis of monoclonal proteins: gel electrophoresis, capillary electrophoresis, immunofixation and nephelometry features, possibilities and limitations are reviewed. The main sources of errors and artifacts during these studies are considered. Also the difficulties in the diagnosis and interpretation of the results of serum and urine tests are highlighted.
Keyphrases
- capillary electrophoresis
- single cell
- cell therapy
- systematic review
- randomized controlled trial
- stem cells
- drinking water
- magnetic resonance imaging
- patient safety
- bone marrow
- hyaluronic acid
- adverse drug
- loop mediated isothermal amplification
- quantum dots
- diffuse large b cell lymphoma
- solid phase extraction
- simultaneous determination
- quality improvement
- smoking cessation