The development status of PET radiotracers for evaluating neuroinflammation.
Namhun LeeJae Yong ChoiYoung Hoon RyuPublished in: Nuclear medicine and molecular imaging (2024)
Neuroinflammation is associated with the pathophysiologies of neurodegenerative and psychiatric disorders. Evaluating neuroinflammation using positron emission tomography (PET) plays an important role in the early diagnosis and determination of proper treatment of brain diseases. To quantify neuroinflammatory responses in vivo, many PET tracers have been developed using translocator proteins, imidazole-2 binding site, cyclooxygenase, monoamine oxidase-B, adenosine, cannabinoid, purinergic P2X7, and CSF-1 receptors as biomarkers. In this review, we introduce the latest developments in PET tracers that can image neuroinflammation, focusing on clinical trials, and further consider their current implications.
Keyphrases
- positron emission tomography
- computed tomography
- pet ct
- lipopolysaccharide induced
- cerebral ischemia
- traumatic brain injury
- lps induced
- pet imaging
- clinical trial
- cognitive impairment
- inflammatory response
- subarachnoid hemorrhage
- deep learning
- brain injury
- machine learning
- nitric oxide
- randomized controlled trial
- functional connectivity
- resting state
- replacement therapy
- smoking cessation
- phase ii