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Synthesis of Naphthalenyl Triflates via the Cationic Annulation of Benzodiynes with Triflic Acid.

Chenxin GeGuohua WangPanpan WuChao Chen
Published in: Organic letters (2019)
A highly efficient and regioselective annulation of benzodiynes promoted by triflic acid has been developed. This protocol provides a step and atom-economic access to a series of naphthalenyl triflates. Furthermore, direct synthetic applications of this reaction are also elaborated through cross-coupling reactions to generate synthetically useful multisubstituted naphthalenes.
Keyphrases
  • highly efficient
  • randomized controlled trial
  • electron transfer