Targeting Refractory Mantle Cell Lymphoma for Imaging and Therapy Using C-X-C Chemokine Receptor Type 4 Radioligands.
Daniel KwonKatsuyoshi TakataZhengxing ZhangLauren ChongBryan FraserJutta ZeislerTomoko Miyata-TakataHelen MerkensJulie RousseauTomohiro AokiHsiou-Ting KuoRuiyan TanChengcheng ZhangJoseph LauDiego R VillaCarlos F UribeKuo-Shyan LinChristian SteidlFrancois BenardPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
CXCR4 is an independent factor of poor prognosis for MCL and a promising target for imaging and radioligand therapy. [68Ga]Ga-BL02 showed high contrast to visualize CXCR4-expressing xenografts for PET imaging and [177Lu]Lu-BL02 induced rapid tumor regression in a preclinical model of MCL.