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Targeting Refractory Mantle Cell Lymphoma for Imaging and Therapy Using C-X-C Chemokine Receptor Type 4 Radioligands.

Daniel KwonKatsuyoshi TakataZhengxing ZhangLauren ChongBryan FraserJutta ZeislerTomoko Miyata-TakataHelen MerkensJulie RousseauTomohiro AokiHsiou-Ting KuoRuiyan TanChengcheng ZhangJoseph LauDiego R VillaCarlos F UribeKuo-Shyan LinChristian SteidlFrancois Benard
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
CXCR4 is an independent factor of poor prognosis for MCL and a promising target for imaging and radioligand therapy. [68Ga]Ga-BL02 showed high contrast to visualize CXCR4-expressing xenografts for PET imaging and [177Lu]Lu-BL02 induced rapid tumor regression in a preclinical model of MCL.
Keyphrases
  • poor prognosis
  • pet imaging
  • pet ct
  • high resolution
  • long non coding rna
  • magnetic resonance
  • cell therapy
  • high glucose
  • magnetic resonance imaging
  • diabetic rats
  • oxidative stress
  • drug delivery
  • photodynamic therapy