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Diagnosis of Familial Dysbetalipoproteinemia Based on the Lipid Abnormalities Driven by APOE2/E2 Genotype.

Ana M BeaAna CenarroVictoria Marco-BenedMartn LaclaustraCsar MartnDaiana IbarretxeXavier PintoTeresa ArrobasClara VialsFernando CiveiraSalvador Olmos
Published in: Clinical chemistry (2023)
The combination of non-HDLc/apoB and triglycerides/apoB ratios is a valuable tool to diagnose DBL in patients with hyperlipidemia with or without lipid-lowering drugs. FDBL diagnosis requires DBL and the presence of a compatible APOE genotype. Most adult APOE2/2 subjects express DBL, making FDBL as common as familial hypercholesterolemia in the population.
Keyphrases
  • high fat diet
  • cognitive decline
  • fatty acid
  • adipose tissue
  • early onset