Frequent loss of claudin-4 expression in dedifferentiated and undifferentiated endometrial carcinomas.
Basile Tessier-CloutierRobert A SoslowColin J R StewartMartin KoebelCheng-Han LeePublished in: Histopathology (2018)
Claudin-4 expression can be absent or very focal in a subset of high-grade endometrial carcinomas, and is almost always absent in the undifferentiated components of SWI/SNF-deficient UECs/DDECs, despite the apparent epithelial origin in the case of DDECs. Therefore, claudin-4 expression cannot be used to infer mesenchymal or epithelial tumour origin in the endometrium. The consistent loss or down-regulation of claudin-4, a tight junction protein, in SWI/SNF-deficient UECs/DDECs further supports the undifferentiated nature of these tumours.