Electroacupuncture: A Feasible Sirt1 Promoter Which Modulates Metainflammation in Diet-Induced Obesity Rats.
Dan LuoLi LiuFeng-Xia LiangZhao-Min YuRui ChenPublished in: Evidence-based complementary and alternative medicine : eCAM (2018)
It is generally accepted that metainflammation, a state of chronic and low-grade inflammation in obesity, plays a great role in metabolic disorder like insulin resistance. To gain further insight into the mechanism of metainflammation and find feasible therapy of obesity, diet-induced obesity (DIO) rats model and Electroacupuncture (EA) treatment were established in this trail. The results indicated that rising Lee's index, hyperlipidemia, insulin resistance, and increasing inflammation factors including NF-κB, TNF-α, and Macrophages 1 were determined in DIO rats while EA is exhibiting an effective intervention. Furthermore, to clarify this phenomenon and provide new recognition of alternative medicine for the treatment of metainflammation, we found that EA activating Sirt1 and Sirt1-dependent deacetylation of histone (H3K9) was the key of modulation. It should be noted that, while possible, the activating of Sirt1 could lead to deacetylation of NF-κB also. In this study, the deacetylation of NF-κB depended on higher level of Sirt1 than H3K9, which suggested that the deacetylation via Sirt1 in metainflammation could be specific and programmed.
Keyphrases
- insulin resistance
- oxidative stress
- high fat diet induced
- metabolic syndrome
- signaling pathway
- high fat diet
- low grade
- type diabetes
- ischemia reperfusion injury
- adipose tissue
- weight loss
- skeletal muscle
- polycystic ovary syndrome
- lps induced
- randomized controlled trial
- pi k akt
- rheumatoid arthritis
- high grade
- neuropathic pain
- stem cells
- nuclear factor
- brain injury
- spinal cord injury
- transcription factor
- physical activity
- subarachnoid hemorrhage
- spinal cord
- toll like receptor
- mesenchymal stem cells
- blood brain barrier
- drug induced