Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes to lipid deposition in nonalcoholic steatohepatitis.

Chaofeng WuJunjie LiHui JiaJiamin ZhaoMengchen QinHao ShiChang LiuJiajie LinMin CaiYong GuBin LiuLei Gao

Published in: Journal of gastroenterology (2024)

Our results demonstrated that effective inhibition of IDO1 expression in macrophages in NASH alleviated hepatic parenchymal cell lipid accumulation and iron deposition, which provided new insights for the future treatment of NASH.

Keyphrases

poor prognosis
single cell
iron deficiency
cell therapy
current status