Compressive mechanical stress enhances susceptibility to interleukin-1 by increasing interleukin-1 receptor expression in 3D-cultured ATDC5 cells.
Yuki TakedaYasuo NikiYusuke FukuharaYoshitsugu FukudaKazuhiko UdagawaMasayuki ShimodaToshiyuki KikuchiShu KobayashiKengo HaratoTakeshi MiyamotoMorio MatsumotoMasaya NakamuraPublished in: BMC musculoskeletal disorders (2021)
Cyclic compressive loading induced mRNA expressions of ADAMTS4 and IL-1R through reactive oxygen species. TRPV4 regulated these mRNA expressions, but excessive compressive loading may impair TRPV4 regulation. These findings suggested that TRPV4 regulates the expression level of IL-1R and subsequent IL-1 signaling induced by cyclic compressive loading and participates in cartilage homeostasis.
Keyphrases
- reactive oxygen species
- neuropathic pain
- induced apoptosis
- binding protein
- poor prognosis
- transcription factor
- high glucose
- cell cycle arrest
- endothelial cells
- diabetic rats
- oxidative stress
- stress induced
- cell death
- endoplasmic reticulum stress
- spinal cord injury
- long non coding rna
- body mass index
- cell proliferation
- physical activity
- weight loss