TP53 mutations are associated with very complex karyotype and suggest poor prognosis in newly diagnosed myelodysplastic syndrome patients with monosomal karyotype.

Yanling RenJinghan WangHua ZhangChen MeiLi YeYingwan LuoXinping ZhouShuanghong ZhuLingxu JiangLu WangJie JinHongyan Tong

Published in: Asia-Pacific journal of clinical oncology (2020)

CK and vCK overlap in most of the MDS patients with MK. TP53 mutations occur more frequently in MDS patients with vCK, and both TP53 mutations and vCK are adverse prognostic factors.

Keyphrases

poor prognosis
prognostic factors
newly diagnosed
long non coding rna
emergency department
protein kinase