Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development.

Xiaojing YangAndré A WeberElvira MennilloPatrick SecrestMax ChangSamantha WongSabrina LeJunlai LiuChristopher W BennerMichael KarinPhilip L S M GordtsRobert H TukeyShujuan Chen

Published in: Environmental health perspectives (2023)

Exposure to iAs in neonatal mice resulted in excessive accumulation of fat in enterocytes, disrupting lipid homeostasis in the serum and liver, revealing the importance of the gut-liver axis and endoplasmic reticulum stress in mediating iAs-induced NAFLD at an early age. https://doi.org/10.1289/EHP12381.

Keyphrases

endoplasmic reticulum stress
early life
induced apoptosis
high fat diet induced
fatty acid
adipose tissue
drinking water
type diabetes
diabetic rats
heavy metals
oxidative stress
wild type
signaling pathway
body mass index
skeletal muscle
metabolic syndrome
drug induced
risk assessment
endothelial cells