Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients.

Jean-Pierre Bellier Yuqi Cai Sarah M AlamThorsten WiederholdArica AielloJonathan S Vogelgsang Sabina Berretta Jasmeer P Chhatwal Dennis J Selkoe Lei Liu

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

We conclude that there is an elevation of TPP tau phosphorylation in AD brains as disease advances. The regional variability of pTPP tau suggests that examining different phosphorylation sites is essential for a comprehensive assessment of tau pathology.

Keyphrases

cerebrospinal fluid
end stage renal disease
protein kinase
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
cognitive decline
white matter
resting state
multiple sclerosis
patient reported outcomes
functional connectivity
mild cognitive impairment
clinical evaluation