Dennis J Selkoe (Dennis Selkoe)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 33

Top Venues

NPJ Parkinson's disease

Science signaling

Proceedings of the National Academy of Sciences of the United States of America

Nature aging

Harvard Medical School

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Harvard Medical School

United States

Vincent and Stella Coates Professor of Neurologic Diseases :: Neurology

Brigham and Women's Hospital

United States

Senior Neurologist :: Neurology

Brigham and Women's Hospital

United States

Co-Director, Ann Romney Center for Neurologic Diseases (formerly the Center for Neurologic Diseases) :: Neurology

Publications

Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom, Wolf N Hahn, Dylan Martin, Maria Ericsson, Arati Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J Selkoe
Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinson's disease 10 (1) (2024)
Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom, Wolf N Hahn, Dylan Martin, Maria Ericsson, Arati Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J Selkoe
Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinson's disease 10 (1) (2024)
Andrew J White, Karis A Clark, Kellianne D Alexander, Nagendran Ramalingam, Tracy L Young-Pearse, Ulf Dettmer, Dennis J Selkoe, Gary P H Ho
A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons. NPJ Parkinson's disease 10 (1) (2024)
Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom, Wolf N Hahn, Dylan Martin, Maria Ericsson, Arati Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J Selkoe
Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinson's disease 10 (1) (2024)
Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom, Wolf N Hahn, Dylan Martin, Maria Ericsson, Arathi Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J Selkoe
Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinson's disease 10 (1) (2024)
Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom, Wolf N Hahn, Dylan Martin, Maria Ericsson, Arati Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J Selkoe
Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinson's disease 10 (1) (2024)
Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom, Wolf N Hahn, Dylan Martin, Maria Ericsson, Arathi Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J Selkoe
Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinson's disease 10 (1) (2024)
Dennis J Selkoe
The advent of Alzheimer treatments will change the trajectory of human aging. Nature aging 4 (4) (2024)
Dennis J Selkoe
The advent of Alzheimer treatments will change the trajectory of human aging. Nature aging 4 (4) (2024)
Andrew J White, Karis A Clark, Kellianne D Alexander, Nagendran Ramalingam, Tracy L Young-Pearse, Ulf Dettmer, Dennis J Selkoe, Gary P H Ho
A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons. NPJ Parkinson's disease 10 (1) (2024)
Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom, Wolf N Hahn, Dylan Martin, Maria Ericsson, Arathi Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J Selkoe
Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinson's disease 10 (1) (2024)
Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom, Wolf N Hahn, Dylan Martin, Maria Ericsson, Arati Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J Selkoe
Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinson's disease 10 (1) (2024)
Andrew J White, Karis A Clark, Kellianne D Alexander, Nagendran Ramalingam, Tracy L Young-Pearse, Ulf Dettmer, Dennis J Selkoe, Gary P H Ho
A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons. NPJ Parkinson's disease 10 (1) (2024)
Gary P H Ho, Erin C Wilkie, Andrew J White, Dennis J Selkoe
Palmitoylation of the Parkinson's disease-associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis. Science signaling 16 (772) (2023)
Nagendran Ramalingam, Shan-Xue Jin, Tim E Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David L Sulzer, Eugene V Mosharov, Weisheng V Chen, Shaomin Li, Dennis J Selkoe, Ulf Dettmer
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity. NPJ Parkinson's disease 9 (1) (2023)
Gary P H Ho, Erin C Wilkie, Andrew J White, Dennis J Selkoe
Palmitoylation of the Parkinson's disease-associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis. Science signaling 16 (772) (2023)
Nagendran Ramalingam, Shan-Xue Jin, Tim E Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David L Sulzer, Eugene V Mosharov, Weisheng V Chen, Shaomin Li, Dennis J Selkoe, Ulf Dettmer
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity. NPJ Parkinson's disease 9 (1) (2023)
Ming Jin, Zhiyun Wei, Nagendran Ramalingam, Meng Xiao, Anqi Xu, Xiaohan Yu, Qingyang Song, Wen Liu, Jianhua Zhao, Dainan Zhang, Dennis J Selkoe, Shaomin Li
Activation of β 2 -adrenergic receptors prevents AD-type synaptotoxicity via epigenetic mechanisms. Molecular psychiatry (2023)
Nagendran Ramalingam, Shan-Xue Jin, Tim E Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David L Sulzer, Eugene V Mosharov, Weisheng V Chen, Shaomin Li, Dennis J Selkoe, Ulf Dettmer
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity. NPJ Parkinson's disease 9 (1) (2023)
Gary P H Ho, Erin C Wilkie, Andrew J White, Dennis J Selkoe
Palmitoylation of the Parkinson's disease-associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis. Science signaling 16 (772) (2023)
Nagendran Ramalingam, Shan-Xue Jin, Tim E Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David L Sulzer, Eugene V Mosharov, Weisheng V Chen, Shaomin Li, Dennis J Selkoe, Ulf Dettmer
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity. NPJ Parkinson's disease 9 (1) (2023)
Jean-Pierre Bellier, Yuqi Cai, Sarah M Alam, Thorsten Wiederhold, Arica Aiello, Jonathan S Vogelgsang, Sabina Berretta, Jasmeer P Chhatwal, Dennis J Selkoe, Lei Liu
Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients. Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
Nagendran Ramalingam, Lisa Brontesi, Shan-Xue Jin, Dennis J Selkoe, Ulf Dettmer
Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models. EMBO reports (2023)
Saranna Fanning, Haley Cirka, Jennifer L Thies, Jooyoung Jeong, Sarah M Niemi, Joon Yoon, Gary P H Ho, Julian Avila Pacheco, Ulf Dettmer, Lei Liu, Andrew T Chan, Kevin J Hodgetts, John N Hutchinson, Christina R Muratore, Guy A Caldwell, Kim A Caldwell, Dennis J Selkoe
Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy. NPJ Parkinson's disease 8 (1) (2022)
Luis Fonseca-Ornelas, Jonathan M S Stricker, Stephanie Soriano-Cruz, Beatrice Weykopf, Ulf Dettmer, Christina R Muratore, Clemens R Scherzer, Dennis J Selkoe
Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons. NPJ Parkinson's disease 8 (1) (2022)
Christian Haass, Dennis J Selkoe
If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline? PLoS biology 20 (7) (2022)
Kelly E Glajch, Tim E Moors, Yi Chen, Pascal A Bechade, Alice Y Nam, Molly M Rajsombath, Thomas D McCaffery, Ulf Dettmer, Andreas Weihofen, Warren D Hirst, Dennis J Selkoe, Silke Nuber
Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proceedings of the National Academy of Sciences of the United States of America 118 (31) (2021)
Dennis J Selkoe
Alzheimer disease and aducanumab: adjusting our approach. Nature reviews. Neurology 15 (7) (2020)
Lei Liu, Li Ding, Matteo Rovere, Michael S Wolfe, Dennis J Selkoe
A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor. The Journal of cell biology 218 (2) (2019)
Ting Yang, Yifan Dang, Beth Ostaszewski, David Mengel, Verena Steffen, Christina Rabe, Tobias Bittner, Dominic M Walsh, Dennis J Selkoe
Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid. Annals of neurology 86 (2) (2019)
Huixin Xu, Molly M Rajsombath, Pia Weikop, Dennis J Selkoe
Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β. EMBO molecular medicine 10 (9) (2019)
Thibaut Imberdis, Joseph Negri, Nagendran Ramalingam, Elizabeth Terry-Kantor, Gary P H Ho, Saranna Fanning, Georgia Stirtz, Tae-Eun Kim, Oren A Levy, Tracy L Young-Pearse, Dennis J Selkoe, Ulf Dettmer
Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase. Proceedings of the National Academy of Sciences of the United States of America 116 (41) (2019)
Dennis J Selkoe
Light at the End of the Amyloid TunnelPublished as part of the Biochemistry series "Biochemistry to Bedside". Biochemistry 57 (41) (2018)

Dennis J Selkoe.css-eqlu8i{font-size:small;padding-left:4px;} (Dennis Selkoe)

Publication Activity (10 Years)

Top Topics

Top Venues

Dennis J Selkoe (Dennis Selkoe)